STUDY OF LIVER PROTECTIVE ACTION OF LIPOSOMAL QUERCETIN AT DRUG-INDUCED EXPERIMENTAL HEPATITES

The study of liver protective action of liposomal quercetin (LQ) was conducted on white rats hepatitis, induced by izoniazid, tetracycline and paracetamol. Research of lipid peroxidation activity, state of the system of antioxidant defence, level of cytolysis and cholestasis, and also synthesizing and detoxicational functions of the liver, showed the expressed therapeutic influencing of LQ. LQ diminishes lethality, normalizes biochemical indices and metabolic processes in the liver at toxic drug-induced hepatitis. The mechanism of liver protective action of the explored mean is connected with both membrane protection and antioxidant influencing. By efficiency LQ excels standard hepatoprotectors used as comparison drugs.