Studying the features of functioning creatine-forming system in the animals irradiated with the dose of 3 Gy has been done. It was detected that irradiation of adult animals with the dose of 3 Gy stimulates sharp reduction of amino acids content, which are the predecessors of creatine synthesis in the liver and kidneys, dicrease in guanidine acetate methylation owing to which the creatine and creatinine content in muscles falls, creatine-kinase activity drops at the expense of KK-MM and mitochondrial ferment form, hyperaminoacidemia, hyperaminoaciduria, creatinuria develop, and sharp reduction of creatinine excretion occurs.
