The paper studied the effect of melatonin on the anticonvulsant activity in different doses. There is studied anticonvulsant effects of antiepileptic drugs in pentilenetetrazol-induced seizures with concomitant administration of melatonin. The study was conducted on white outbred mice-male weighing 21–23 g. In studying the effect of melatonin on seizure activity, it was shown that it induces a dose-dependent effect. Melatonin increases the duration of the latent period of onset seizures. In the study of the combined effect of melatonin enhances the anticonvulsant effect of phenobarbital and retigabine and does not affect the anticonvulsant effects of valproale. There are studied side effects of melatonin and its combination with antiepileptic medications.
