Application of thiotriazoline against a background of basic therapy with metoprolol is justified in cases when duration of interval R-R on ECG < 898 мс (87 %), thickness of the posterior wall of the left ventricle in diastole < 1.32 cm (83 %), fraction of emission of the left ventricle < 59 (94 %) and the nitrites level in blood plasma > 0.62 mmole/l (84.2 %). In order to increase metoprolol efficiency it is expedient to use trimetazidine when the size of dispersion interval Q-Т > 52 мс (94 %), the nitrites level in the blood plasma > 1.24 mmole/l (94 %) and the size the final-systolic volume of the left ventricle > 94 ml (89 %).
