Introduction. Epstein-Barr virus infection (EBVI) is one of the most common infectious human diseases. Antibodies to Epstein-Barr virus (EBV) is found in 60% of children in the first two years of life and in 80–100% of adults. In recent years, described congenital Epstein-Barr virus infection. It is established that the risk of the primary EBVI during pregnancy is 67%, with reactivation — 22%. Most EBVI reactivation during pregnancy accounts for I, II trimesters of pregnancy.
The goal of research — to analyze complications of the first and second half of pregnancy in women on the background of Еpstein-Вarr virus infection.
Materials and methods. There were examined 250 pregnant women, delivered in Uzhgorod city maternity hospital in the period of 2014–2015. We used modern methods, enzyme immunoassay (ELISA) and polymerase chain reaction (PCR). There are determined the presence of antibodies to IgM and IgG capsid, nuclear and EBV early antigen (VCA, EBNA, EA VEB), IgG antibodies avidity to EBV capsid antigen (VCAVEB) and EBV DNA (DNAVEB) in the blood of pregnant women.
Results and discussion. The study of specific immunity revealed the presence of antibodies to EBV in all pregnant women (100%). Every third woman bore EBVI active. A prospective clinical and statistical comparative analysis of pregnancy in 106 pregnant women who were divided into two groups. The I group included 71 pregnant activation of EBV infection and control group (CG) consisted of 35 pregnant women with latent EBV infection. The average age of women KG was (23.5±1.6) years, and in the I group the figure was significantly higher — (27.4±1,3) years (p<0.05). A prospective clinical and statistical analysis showed that pregnancy in women with reactivation of chronic persistent infection WEB proceeds with a significantly higher rate of complications such as the threat of termination of pregnancy (56.3%), gestational anemia (54.9%), placental dysfunction (63.3%), threat of premature birth (53.5%), intrauterine growth retardation — asymmetrical shape (39.4%).
Conclusions. The results indicate a fairly high frequency of obstetric and perinatal complications gestation in pregnant women with persistent EBV reactivation of chronic infection.