Background. The role of matrix metalloproteinase-13 (MMP-13), tissue inhibitor of metalloproteinase-4 (TIMP-4) and tenascin C (Tn C) in patients with acute myocardial infarction (AMI) and diabetes mellitus (DM) type 2 remains an understudied area.
The aim of research is the assessment of intercellular matrix and its links with cardiohemodynamic parameters in patients with acute myocardial infarction and type 2 diabetes mellitus following determination of matrix metalloproteinase-13, tissue inhibitor of metalloproteinase-4 and tenascin C.
Materials and methods. The study involved examination of 60 patients with AMI and DM type 2, 40 patients with AMI and without DM type 2 and 20 substantially healthy subjects. The content of MMP-13, TIMP-4 and Tn C was established by enzyme-immunoassay. Cardiohemodynamic parameters were determined by ultrasound scanner “ULTIMA PRO-30” produced by “Radmir” JSP Research Institute of Radio Engineering Measurements.
Results and discussion. The study provided a possibility to determine a direct correlation between MMP13 and end-diastolic volume (EDV) (r=0.57, p<0.05); end-systolic volume (ESV) (r=0.55, p<0.05), end-diastolic dimensions (EDD) (r=0.61, p<0.05), end-systolic dimensions (ESD) (r=0.56, p<0.05), stroke volume (r=0.47, p<0.05), interventricular septum thickness (r=0.37, p<0.05), left ventricular mass index (r=0.43, p<0.05), left ventricular mass (r=0.53, p<0.05), (r=0.56, p<0.05), relative thickness of the posterior wall of the left ventricle (r=0.62, p<0.05). Correlation analysis showed a direct relationship between the level of TIMP-4 and interventricular septum thickness (r=0.38, p<0.05). The study showed a direct correlation between Tn C on the 1st–2nd day and stroke volume (r=0.58, p<0.05).