The purpose of research — to examine the state of lipid metabolism and constitutional parameters in patients with ischemic heart disease and obesity, depending on the genotype polymorphism of endothelial nitric oxide synthase (Glu298Asp).
Material and methods. There have been a comprehensive survey of 222 patients with ischemic heart disease. Comparison group consisted of 115 patients with ischemic heart disease with normal body weight. The control group included 35 healthy individuals. All patients underwent general clinical and instrumental examination. Echocardiographic studies were performed by the standard method for H. Feigenbaum ultrasound devices RADMIR. The statistical processing of results was performed with the help of software package “Statistica” (StaSoftInc, USA). The values calculated: the average (M), dispersion, standard deviation, the median (m), accuracy and level of significance (p). The standard programme of correlation analysis with calculation of average arithmic means was used: M±m, у, and level of accuracy (p). Pearson correlation coefficient was applied to evaluate the interaction stage between the samples (r).
Result. We have not been established relationship between volume of neck, waist, hips, levels of total cholesterol, triglycerides, low density lipoprotein cholesterol, high and very low density cholesterol and genotype polymorphism of the gene eNOS (Glu298Asp) in patients with ischemic heart disease and obesity.
Conclusion. We have not established relationship between anthropometric parameters and genotype polymorphism of the gene eNOS (Glu298Asp) in patients with ischemic heart disease and obesity and not found associations with metabolic lipids.