An experimental use of the developed method of simulating gastroesophageal reflux disease is accompanied with the development of pathohistologic changes typical of reflux-esophagitis. The course of an inflammatory process at early stages of its development is characterized by a predomination of alterative changes in the tissues of the esophagus, which spread through out its all layers. The evidence of a long-lasting influence of the acidic-peptic factor is the visualization of erosions and ulcers, that appear at different stages of development.
