Introduction. The sufficient calcium and vitamin D supply of patient is an important element in the prevention and treatment of bone fractures, especially at osteoporotics, but certain studies indicate that the vitamin D level is insufficient at the majority of patient over age 50.
Objective is to determinate the relationship between mechanical strength of the bone tissue, leptin level, osseous remodeling markers in postmenopausal women with the supply with vitamin D, and effect of calcium supplements and vitamin D on the remodeling markers.
Methods. 25 women (50 to 60 years old), who were hospitalized after falling down, were involved in study. 8 patients (main group) had fractures of limbs and the lumbar vertebral compressive fracture. The comparison of pain syndrome intensity, state of the locomotor apparatus, osseous remodeling markers, leptin and vitamin D levels with the control group (17 patients) was realized.
Results. The group of patients with fracture (8 patients) revealed a more intense pain syndrome, lower leptin and vitamin D levels, higher osseous remodeling markers level (deoxypyridinolin, osteocalcin and osseous alkaline phosphatase).
Conclusion. Use of the calcium and vitamin D during 3 months resulted in reduction of the pain intensity, the rise of vitamin D level and the decline of osseous remodeling markers.