The investigation of the effects of quinazoline derivatives (Terazosin, Prazosin, Doxazosin, Alfuzosin) on rat’s vascular tone and blood pressure in comparison with a leading targeted quinazoline-derived drug Erlotinib (Tarceva), used to treat human non-small cell lung carcinoma, are presented in this article.
All quinazoline derivatives were shown to possess ability to inhibit the phenylephrine-induced contractions of isolated rat blood vessels. This effect was revealed for Erlotinib.
The quinazoline derivatives possess a dual action — impact on the rat vascular tone and blood pressure (α1-adrenoceptor antagonists) in comparison to potent anticancer activity of Erlotinib, used for treatment of human non-small cell lung cancer. These findings suggest advisability of further comparative investigations of their antitumor activity for possible expanding the clinical indications.