Today many observations of neurological and neurosurgical clinics have concluded a significant increase in prevalence of the central and peripheral nerve system damage. One of the main places is occupied by compression neuropathy (CN). The problem of the effects of the CN does not lose its current value. One of the main clinical manifestations of the CN is a neuropathic pain, which significantly impairs the quality of life of patients. In the development of these manifestations the main role belongs to irreversible damage to the peripheral sensory fibers and neurochemical changes in the metabolism of neurons in spinal cord (SC).
The aim of this study was to investigate the changes in the excitability of interneuron pool at early stages of the experimental CN.
The study used a standard electrophysiological techniques.
The results showed that in experimental CN is a change in the activity of neurons in the posterior horns of the SC, which is a decrease in the threshold of the dorsal surface potential (DSP=(1.11± ±0.06) mA) to a minimum on the 10th day of the experiment. Changes of DSP chronaxy ((62.67± ±8.40) ms) for 5th day of CN indicate the likely change in the biophysical properties Na+-channels, and require more detailed study.
Thus, it can be concluded that the metabolic conversion in CN lead to lowering of the threshold of excitation and irregularities in the functioning of afferent conductors and SC interneuron pool.