VALUE OF M. TUBERCULOSIS GENOTYPING

The aim of present study was to obtain genetic profiles of Mycobacterium through detection of six VNTR-loci and determine the peculiarity of the genotype of drug-resistant strains.

Loci MIRU10, MIRU26, MIRU40 і ETR A have exhibited high polymorphism in group non-Beijing, while loci MIRU26 and MIRU31 — in Beijing family. Among Beijing family isolates there were such clusters as 355335, 355344, 355345, 356335, 356344, 375334, 375344, 385345, 385334. Clusters 355335, 375334 and 385334 have had high level of multi-resistance and mutations in katG and rpoB genes. The most spreading cluster among non-Beijing isolates was 452242, that have had high level of multi-resistance and mutations in katG and rpoB genes.