The study was aimed to assess the role of insulin-resistance in the determination of the peculiarities of PCOS course. There was demonstrated that НОМА-IR is in three folds (2.4±0.1) higher among PCOS patients as compared to healthy females. The females having homozygote genotype by the functional polymorphisms rs189282 and rs939609 have increased insulin-resistance and more severe disease course. Whereas the indices of insulin-resistance were not correlated with the values of other indices of metabolic and hormonal profile. There is discussed a possibility to use the rate of insulin-resistance for determining patients requiring metabolic correction in the complex treatment of PCOS.
