Preparations containing fluorine are widely used to prevent main stomatological diseases. In recent years there have been developed new fluorosilicate prophylaxis for dental caries, including biologically active “onium” cations possessing different types of antibacterial activity.
The aim of this study was an experimental study in rats on a background of non-toxicity of cariogenic diet designed for use in the practice of dentistry oral gels.
Materials and methods. In the experiment there were used fluoride preparations belonging to the mucous-adhesive gels. It was used 56 Wistar white rats. Evaluated 35 days: gain of mass, maintenance in blood the level of red blood cells, protein, lysozyme activity, elastase, alanine transaminase, alkaline phosphatase, and malondialdehyde level.
Conclusions. It was revealed almost complete absence of toxic effects in the chosen dosage fluorosilicate (1.36 mg fluorine/kg per day) and the applicator mode of administration. Taking into account the higher caries preventive activity of hexafluorosilicates, superior to similar activity of sodium fluoride by 35–36%, it can be assumed that these drugs will take a worthy place in the arsenal of measures for the prevention of dental caries.