Pharmacokinetics in blood and biodistribution in organs of mice i. v. administrated glucosaminylmuramyl dipeptide (GMDP) both free and entrapped in phosphatidylcholine liposomes were studied. GMDP embedding into liposomes resulted in enhancement of elimination half-life t1/2β, area under the pharmacokinetics curve values AUC, mean residence time MRT and caused peptide retention in organs. The size of liposomes effected on expressiveness of those pharmacokinetics parameters.
