At the restoration of chronic fluorine intoxication (CFI) by the consuming table water, containing NaF in concentration of 20 mg/l, during a month, the reduction of the activity of alkaline phosphatase (AlP), the general proteolytic activity (GPA) and the increase in activity of acid phosphatase (AP) and elastase (E) in osseous tissue of thigh were determined. The taking of the one of the calcium preparations (Ca citrate, 500 mg/kg, Ca carbonate, 250 mg/kg and natural limestone) has resulted in the considerable reduction in activity of AP and E and to the growth of the indices of mineralization (AlP/AP) and collagen formation (GPA/E), but hasn’t restored them to the level of intact animals.
