Introduction. Pharmacological properties of new alkylthio-derivatives were investigated in comparison with the same in 1,3,4-benztriazepine-2-ones and -2-thiones.
The aim of the work was studying new neurotropic properties of alkylthio-derivatives 1,3,4-benztriazepine compared with 1,3,4-benztriazepine-2-thiones and -2-ones.
Materials and methods. The study was conducted on white outbred mice weighing 18–20 g, and rats weighing 180–220 g, which were kept under normal conditions vivarium on a standard diet. The animals of the control group were administered saline and other animals — test compound as a suspension of Tween — 80 intraperitoneally in doses of 1–10 mg/kg. General motor activity was studied with the “open field” test, anticonvulsive — by antagonizing korazol, antidepressant — with “Porsolt forced swimming” method, anorexia activity — by the method of Milanie Dezube, as a comparator it was used phenazepam 0.1 and 0.3 mg/kg.
Results. Among the investigated substances there were found compounds that have a wide spectrum of pharmacological activity including sedative, anorexigenic and depriming efficacy. The investigated compounds do not exhibit anticonvulsive activity in the dose ranging from 1.0 mg/kg till 10 mg/kg. Some of them reduce in half the general motor activity pertaining with the control animals. The investigated compounds revealed both anorectic and orectic properties depending on their chemical structure.