The first step in creating a new drug is the synthesis of new promising compounds and the study of its physical and chemical properties. One promising avenue is the synthesis of 1,2,4-triazoles 3-iltioacetic acids. Therefore, in order to create new high-performance and low-toxic compounds were synthesized 2-((4-(R-amino)-5-(thiophene-2-ilmethyl)-4H-1,2,4-triazole-3-il)thio)acetic acids, where R — 2H, 1-feniletiliden, benzyliden, 4-dimetylaminobenzyliden, 4-fluorbenzyliden, 2-hydroxybenzyliden, thiophene-2-ilmetylen, 3,4-difluorbenzyliden, 2-chloro-6-fluorbenzyliden, 4-metoxybenzyliden 3,5-dimetoxybenzyliden, 1-(4-aminophenyl)etyliden, 1-(4-fluorophenyl)etyliden with modern physicochemical methods of analysis set structure.
Materials and methods. The study of physical and chemical properties of the compounds obtained were carried out according the methods described in the State Pharmacopoeia of Ukraine.
The experimental part. 2-((4-(R-amino)-5-(thiophene-2-ilmethyl)-4H-1,2,4-triazole-3-il)thio)acetic acids were synthesized by the addition of 2-chloroacetic acid to equivalent amount corresponding 4-(R-amino)-5(thiophene-2-ilmetyl)-4H-1,2,4-triazole-3-thiols previously dissolved in a solution of i-propyl alcohol and sodium hydroxide.
Results and discussion. The structure of the synthesized compounds confirmed our complex modern physical and chemical methods of analysis (elemental analysis, 1H-NMR-spectroscopy, and their personality — by HPLC-MS).
Conclusions. A series of new 2-((4-(R-amino)-5-(thiophene-2-ilmethyl)-4H-1,2,4-triazole-3-il)thio)acetic acids were synthesized. The structure of the synthesized compounds determined by modern physical and chemical methods of analysis.