In the experiments carried out on the 44 male white nonlinear rats with body weight of 0.16–0.18 kg with hepatorenal syndrome under the condition of the acute hemic hypoxia of the moderate degree, the defensive prophylactic influence of the medication GA-40 has been established, which reveals in antyoxydative action, lowering activity of protelyosis, in the concentration of the tumour necrosis factor alfa in plasma, the resumption of the activity of alkaline phosphatase in cortical area of the kidneys and the activity of succinate dehydrogenase in the third functional region of the liver lobule, connected together with the positive correlative bound with the equation of regressive analysis: alkaline phosphatase (cortical region of the kidneys) = 145,8±1,56 succinate dehydrogenasa; r=0,976; n = 11; P<0,001.
