LIPOSOMAL GLUCOSAMINYLMURAMYL DIPEPTIDE ACCUMULATION IN ORGANS AND TISSUE MACROPHAGES AFTER INTRAVENOUS ADMINISTRATION IN MICE

Biodistribution in organs and accumulation in macrophages of GMDP entrapped in phosphatidylcholine liposomes were studied by method of double isotopic tracer (14С/125I). Peptide release from liposomes in blood was established up to 90 % for 6 hours. At the same time, liposomal peptide eliminated gradually from blood, retained in the liver, spleen and lungs and accumulated in macrophages of these organs.