New data about beginning and physiologic mechanisms of menstrual function, pathogenesis of pathologic uterine bleedings are presented. It was detected the role of sex steroid hormones, growth factors, prostaglandins, lisosomal enzymes, local and system hemostasis in etiology of anovulatory and ovulatory uterine bleedings, organic pathology as a basis of abnormal uterine bleeding.
There were established positive effect of using levonorgestrel-releasing intrauterine system to prophylaxis and treatment of pathologic uterine bleeding in case of non-atypical endometrial changes, small intrauterine myomas, adenomyosis, non-atypical endometrial hyperplasia.