There were examined 62 patients suffering from rheumatoid arthritis with concomitant esophageal damage and the term of the disease from4to 15 years. The rheumatoid arthritis patients had the difference in the levels of nitrits (final metabolites NO) in an organism, in the blood serum. The changes like this are the evidence of metabolic dysbalance between NO formation and utilization in rheumatoid arthritis, which leads to the lower esophageal sphincter dysfunction as a target of NO mediator action and to injury of the esophageal mucosa as the area of the NO cytotoxic action influence.
