It was shown that seizures induced in three weeks from the moment of precipitation of generalized seizures via kindled соrazol administration (30.0 mg/kg. i. p., during three weeks) were resistant to diazepam action which in a dosage of 0.5 mg/kg (i. p.) did not protect from seizures induction in response to testing epileptogen administration. At the same time, diazepam dosage, which did not cause antiseizure action (0.1 mg/kg, i.p.) being administered together with pentoxyphillin (PTPh) (50.0 mg/kg, i. p.) prevented the incidence of generalized clonic-tonic manifestations in 53.3 % of experimental animals. Combined administration of diazepam and PTPh diminished the postseizure locomotor depression depermined in “open field” test.
