MATHEMATICAL MODELLING AND EXPERIMENTAL GROUND OF OPTIMUM REGIMEN DOSAGE OF COORDINATING COMPOUND OF GERMANIUM WITH PYRACETAMUM AT CEREBRAL INFARCTION

Pharmacometric researches on definition of an optimum mode of dosing of coordination compound of germanium with pyracetamum (VITIN-1) allowed to establish that introduction of this potential cerebral protector in a doze of 114.9 mg/kg in 20.43 min after the common carotids occlusion in maximal degree realizes the increase in average life expectancy of animals under conditions of acute ischemia of the brain.