The study was dedicated to efficacy analysis of the use of adhesion barriers in adhesive process associated with external genital endometriosis, stage III–IV during endosurgical treatment.
Group I consisted of 60 infertile patients with external genital endometriosis, stage III–IV who during surgery were applied hemostatic material “Gynecare interceеd” of sufficient surface to cover a traumatized zone, in 70 patients of group ІІ during surgery antiadhesive gel “Ethicon Intercoat” was applied with the help of applicator. Group III consisted of 70 patients who received a standard surgical treatment.
Analysis of obtained results showed that interleukins IL-6, IL-10 level in examined patients are a marker for adhesive process prior to operation. Intraoperational use of adhesion barriers leads to decrease in inflammatory activity markers as verified by proinflammatory cytokines Il-6 and IL-10. Intensiveness of pain syndrome positively lessens as compared to preoperative values: in group І (5.38±0.25; 3.33±0.25; р<0.001) and in group ІІ (5.49±0.25; 2.83±0.25; р<0.05). Group ІІІ also showed tendency to lessening — (5.17±0.25; 4.23±0.25).
Figures for reproductive function recovery did not significantly vary in groups with the use of different adhesion barriers and corresponded to in group І — 28 (46.6%), in group ІІ — 32 (45.7%), in group ІІІ — 19 (27.1%) (c2=6.89; df=2; р=0.03).
Therefore it is rational to recommend introduction of adhesion barriers into surgical treatment of infertile patients with adhesive process associated with external genital endometriosis stage III–IV.