The rats were given the preparation, containing the polyphenole substances of grape extracts “Extravin” dosed at 1ml/kg of alive weight 2 weeks before the taking of antibiotic lincomycin with table water.
The activity of urease, lysozyme, and the level of the markers of inflammation (malonic dialdehyde, the general proteolytic activity and acidic phosphatase) were determined in the mucous membranes of the oral cavity and the small intestine.
The degree of disbiosis was estimated by the ratio of the relative activity of urease and lysozyme. The preliminary introduction of “Extravin” prevents the development of disbiosis in all the studied tissues and normalizes the level of the inflammatory markers.