Introduction. In the literature there are defined positive shifts in our understanding of the fetal growth retardation pathogenesis and markers of this complication in early terms of pregnancy sources, possibility of the early beginning of the pathogenetic treatment is revealed, allowing to hope for perinatal pathology possible decrease at high risk groups of women.
The research objective — to find out new aspects of the fetal growth retardation pathogenesis on the serum growth factors and vasoactive substances study basis.
Materials and methods. We carried out complex clinical-laboratory and functional investigation of 200 pregnant women which have been divided in two groups: control — 100 women with physiological pregnancy and labors, and also the main group — 100 pregnant women with fetal growth retardation.
Results and conclusions. Results of our research testify that the established new aspects of fetal growth retardation pathogenesis allow us to explain the increase of mentioned pathology during last years, and also insufficient standards in forecasting, treatment and prophylactic methods. The angiogenic growth factors and vasoactive components production changes in fetal growth retardation come to light for preclinical stages, long before obstetrical complications clinical demonstration and can serve as screening markers. The received results are scientific substantiation for tactic improvement at fetal growth retardation forecasting, treatment and prophylactic actions.