White rats were administered the pesticide 2,4-DA in the dose of 1/10 from LD50 during 15 and 30 days in experiment as a model of chronic intoxication. Under influence of prolong administration of the pesticide 2,4-DA the activation of lipids FRPO processes in testis tissues and blood and antioxidant enzymes activity suppression were observed. At morphological studies, disorders in testis structure were revealed, which has a free-radical mechanism. This investigation is basis for research of agents with antioxidant activity at 2,4-DA chronic intoxication.
