The study of functional status of enzymatic systems detoxifying xenobiotics has been conducted with the aim of investigating the correlation between enzymatic activity of glutathione system in 52 healthy newborns and 56 newborns with intrauterine growth restriction (IUGR) syndrome. The glutathione system includes reduced glutathione and enzymes which provide regeneration of reduced glutathione from the oxidized form: glutathione peroxidase (GPO), glutathione reductase (GRD) and glutathione-S-transferase (GST). The study revealed that the GPO and GST activity levels in healthy newborns were 1.35 and 2.03 times higher (р<0.05). The tendency for GRD enzyme predominance was noticed in healthy newborns from Precarpathian region as compared to IUGR newborns. The obtained findings may be the indicative of better functioning of antiradical protective systems in healthy newborns in comparison with IUGR ones.
