Introduction. According to current recommendations, lipid-lowering therapy is considered as base for treatment of atherosclerosis. Statins are recognized leaders in lipid-lowering effects, however their impact on high-density lipoproteins is insignificant. Fibrates, on the contrary, have a more positive impact on this factor, as well as on triglycerides, for which reason it seems reasonable to use a combination of statins and fibrates. This combination is rarely used in medical practice though for fear of increased side effects and reduced quality of life in the patients.
The research objective — is to study the impact of the combination lipid-lowering therapy on mental health indicators of the quality of life in patients with stable angina pectoris.
Мaterials and methods. The study involved 64 patients with stable angina, mean age (58.52± ±1.53) years. Group I (n=32) received a standard set of medications for patients with stable angina acompanied by atorvastatin 20 mg daily; group ІІ received atorvastatin in a reduced dose of 10 mg per day and fenofibrate in a dose of 145 mg per day. The patients subjectively assessed their condition using the MOS SF-36 questionnaire.
Result and conclusions. While there were improvements marked on the mental health scales by patients receiving atorvastatin in combination therapy, the integral mental health indicator did not change (p=0.98). A tendency towards reduced indicators of emotional role functioning and mental health along with increased anxiety and depression was only observed in patients receiving a combination therapy with statins and fibrates. This made it impossible to achieve adequate levels of quality of life under the scales for mental health and the integral mental health indicator, which did not change significantly (p=0.59). The above prompts introduction of additional methods of influence to correct the mentioned abnormalities.