We studied the influence of cytokine immunocorrector recombinant interleukin-2 (Roncoleukin) (0.01 mg/kg) on the parameters of the thiol-disulfide system (TDS) in terms of modeling alloxan diabetes in rats in comparison with Piracetam (500 mg/kg). For in-depth analysis of the status of individual links of TDS in the postischemic disturbances in brain tissue of rats with DM there were studied levels of reduced and oxidized thiols and glutathione, the activity of glutathione peroxidase (GPX) and glutathione reductase (GR), and additional parameters TDS — classic thiol-disulfide ratio (TDS) and offered us the original factors — reduction potential TDS (EAP) and the index of the glutathione system (IGS). The proposed indicator EAP characterizes the ratio of the concentrations of reduced forms of glutathione and thiols to their oxidized forms, and allows to assess the state of the first nevermelting link TDS. Index GCI characterizes the total state afermative/permutative links glutathione antioxidant system is the ratio of the concentrations of reduced forms of glutathione together with indicator GP and SNR in the concentration of oxidized glutathione. It is established that the postischemic tissue damage of the brain of an experimental animal model with alloxan diabetes was accompanied by a sharp decrease (96–94%) of the studied parameters. In importance as the backbone of the results of the original coefficients of the EAP and the GCI exceed the standard rate TDK and can be used as early markers of formation of post-hypoxic changes in DM and violations of the RTD activity of brain tissue, and to study the antioxidant activity of potential neuroprotective agents — antihypoxant corrective effect of Piracetam, Tietema and Roncoleukin on the results of the original coefficients TDS — EAP and GCI, the most pronounced at Roncoleukin.
