Changes of the matrix metalloproteinases MMP-2, MMP-9 activity and level of hyaluronic acid and heparin in the rat blood with induced chronic hepatitis as well as the influence of glutargin were investigated. It was shown that coefficient of MMP-2/MMP-9 is more informative in the liver disease than the activity of MMPs in themselves (1); change of hyaluronic acid reflects the liver fibrogenesis (2); glutargin increases the liver reparation and may be recommended as antifibrotic therapy (3).
