There was simulated in rats the disbiosis with the use of antibiotic, toxic hepatits at introduction of hydrazine or the combination of hepatitis and disbiosis. The state of periodontal soft tissues (gum’s) was estimated according to the level of biochemical indices, the state of inflammation, dystrophy and disbiosis, and the one of osseous tissue — by the degree of atrophy of alveolar appendage, changes in phosphatases and proteases activity.
Oral disbiosis, development of inflammatory-dystrophic processes in gum, oppression of the processes of mineralization and activation of the processes of collagen formation in the osseous tissue were revealed. The conclusion on the considerable role of the liver in pathogenesis of periodontal diseases is drawn.
