At the basis of own elaborated experimental model of peptic ulcer in combination with diabetes mellitus in rats pathogenetic mechanisms of stomach mucus barrier damage have been studied. The sialoproteins degradation increase, proteoglicans production decrease was established against a background of proteinase-inhibitional disbalance. The extent of these pathogenetic mechanisms of resistance weakening of stomach mucus membrane is more pronounced under the condition of combination of peptic ulcer and DM, than for rats with experimental peptic ulcer.
