Objective — studying and evaluating fatty-acid composition of plasma lipids in patients suffering from fibrosocavernous pulmonary tuberculosis.
Materials and methods. There were examined 103 (53.9%) healthy persons (first group) and 88 (46.1%) of patients with fibrocavernous pulmonary tuberculosis (second group). Examination of patients was carried in the Kyiv City TB Dispensary. Fatty-acid composition of plasma lipids was studied by the biochemical method using a gas-liquid chromatograph “Tsvet-500”.
Results and discussion. There were revealed essential changes in fatty-acid spectrum of plasma lipids in fibrocavernous pulmonary tuberculosis patients. Significant reduction in saturated fatty acid contents against a background of an elevation in total unsaturated fatty acid level as well as total polyunsaturated fatty acid level as a result of augmented activation of the lipid peroxidation processes have been revealed. The amount of palmitic (C16:0) fatty acid reduction up 1.74 times (р<0.001), stearic (C18:0) fatty acid reduction up 1.89 times (р<0.001) as compared with the control group. The amount of arachidonic (C20:4) fatty acid grows up 1.74 times (р<0.001), linoleic (C18:2) fatty acid and oleineic fatty acid reduction up 3.23 times and 1.87 times (р<0.001) as compared with the control group.
Conclussions. Lipid metabolism is important in the development of fibrocavernous pulmonary tuberculosis, which is manifested by a change in fatty acids in plasma and must be considered during the treatment of these patients and there is the prospect of our research. Fatty acids in plasma should be determined in order to assess the nature of the metabolic processes and establish the severity and consequences of the disease.