The study shows the opposite effect of EGF and its agonists — herceptyn and teralok on proliferation, adhesion and glucose consumption by tumor cells of breast cancer MCF-7 in the serum free medium. Thus, EGF increased the subpopulation of proliferative pool (G2 / M + S) 1.5 folds and 3 folds reduced the apoptotic index. There were increased adhesive properties of MCF-7 by 42% under the EGF influence and decreased glucose consumption by 21%. Herceptin and teralok inhibit cell proliferation, increase the percentage of cells in apoptosis without affecting the adhesive potential, however, they increase the glucose absorption by tumor cells in the serum free medium.