Cohort study of risk factors and peculiarities of course of the disease in children with confirmed antenatal HIV transmission was done. Risk factors of antenatal HIV transmission include prematurity, IUGR, advanced HIV stages in pregnant women, chronic placental insufficiency and presence of infections. Main clinical manifestation of inborn HIV infection is generalized bacterial infections. Risk of death in children with antenatal HIV transmission is increased. Premature newborns and children with IUGR must be tested by PCR test during newborn period. It will make the possibility to start HAART early to HIV infected children.
