In experiments on female rats was shown that gastric mucosal defence has negative correlation with estrogen level. Gonadectomy decreases the production of GAG, nitrite/nitrates, and SOD activity and at same time increases MDA level and gastrointestinal permeability. Ulcerogenic effect of diclophenac sodium, nimesulid and celecoxib increased after castration and decreased after substitutive and excessive introduction of estradiole. An example of diclophenac sodium demonstrates that gastrotoxic action closely correlates with the level of vasodilating and vasoconstrictive molecules expression.
