The aim of the study was to evaluate levels of tissue plasminogen activator, type 1 plasminogen activator inhibitor, soluble fibrin (SF) and D-dimer in 60 essential hypertension (EH) patients aged 27–68 years. 21 patients (group one) have low cardiovascular risk, 39 — high/very high cardiovascular risk. Antigen and activity of t-PA, levels of SF and D-dimer were found to be hyperactive in patients of the 1st group (all P<0.05). Antigen of tissue plasminogen activator, type 1 t-PA inhibitor, levels of SF and D-dimer we found to be hyperactive (all P<0.05), while t-PA activity was suppressed (P<0.05) in EH patients with high cardiovascular risk (2 group).
