The morphological analysis of pathomorphological processes in the mucous membrane of the stomach in rats with an experimental ulcer for Takayashu is conducted. Histochemical research of the i-NOS activity is produced in a periulcerous area mucous. In the mucous membrane of periulcerous area there were observed the phenomena of apoptosis cells, severe leucocitar infiltration, dilatation of arterioles, capillaries and venules, diapedesis bleedings. Sharp increase of the i-NOS activity in the periulcerous area of mucous and phenomena of vascular permeability increase were detected. The reveled signs can be used in the further research of effective methods of treatment and prognosis of the gastroduodenal bleeding.
