Recently the problem of ecological safety of the human is the more actual: intoxication with chemicals of anthropogenous origin increases. Means of chemical protection of plants, such as pesticides, namely derivatives of 2,4-phenoxyacetic acid (2,4-DA), are important among other ecotoxicants.
The purpose is to study influence of synthetic antioxidants (SA) on biochemical indicators in blood and brain of rats at long influence of amine salt 2,4-DA.
The experiment was conducted with 60 rat males were administered a toxicant (amine salt 2,4-DA) and synthetic antioxidants thiotriazoline and mexidol. In the blood and brain tissues it was examined the level of spontaneous haemolysis of erythrocytes and the products reacting with 2-thiobarbituric acid, and the activity of catalase, SOD and ceruloplasmin.
The results indicate the possibility of using synthetic antioxidants mexidol and thiotriazoline with the prophylactic and therapeutic purposes at the toxic effects of pesticide amine salt 2,4-DA on the organism.