In spite of high quality of methodical and technical means of X-ray therapy, X-ray stomatitis development is the basic problem in management of anticancer therapy. It takes place in patients who had X-ray therapy associated with cancer at the region of head and neck. And prophylaxis and medical treatment of radiation defeats are not always effective.
Purpose of this research is studying the effect of a new agent for the oral care on the level of biochemical markers of inflammation and restoration processes in the oral mucosa under conditions of X-ray stomatitis.
Materials and methods. Experiments were conducted on 50 white rats exposed to the rays AGAT-R1 under doses of 10, 15 and 20 Gy. A clinical picture of X-ray stomatitis in animals and influence of the new hygienic agent on the biochemical indices of inflammation, peroxidation, antioxidant protection of the oral mucosa have been studied.
Results
1. With local action on oral tissues at X-ray stomatitis in rats, the new hygienic agent improved quick disappearence of irradiation oxidative stress and normalized activity of antioxidant enzymes activity.
2. Under experiment conditions the new gel had a local protective action on the course of erosive-ulcerous X-ray stomatitis and assisted in cicatrization of oral mucosa.
3. The obtained results indicate the perspectiveness of the new agent application for the oral cavity in case of medical treatment of erosive-ulcerous elements of X-ray injury of the oral mucosa.