The results of chronic studies demonstrate that administration of PABP (0.1 and 0.5 mg/kg dosage i/p) results in delayed formation of generalized epileptic syndrome caused by kindling corasole administration (dosage 25.0 mg/kg, i/p). After a 7-day interval in epiloptogen’s dosing rats that received PABP demonstrated high epileptic activity, similar to control group parameters. At early stages of corasole-induced kindling PABP demonstrated dose-dependent inhibition of corasole-induced convulsions. In delayed kindling (3 weeks after last corasole dosing) PABP demonstrated antiepileptic activity when given in 0.5 mg/kg dosage.
