Objective: Studying development and expression proliferation marker Кі-67, ER, PR in epithelial and stromal endometrium at hyperplasia processes and their prognostic significance determination.
Materials and methods. An immunohistochemical investigation of endometrium was done in 74 women. The main group consisted of 60 women with hyperplasia of endometrium and adenocarcinoma (11 — simple hyperplasia without atypia, 18 — complex hyperplasia without atypia, 10 — simple hyperplasia with atypia, 13 — complex hyperplasia with atypia, 8 — adenocarcinoma), the control group consisted of 15 patients with morphological unchanged endometrium (proliferation stage n=6, secretion stage n=9). We defined proliferation markers Кі67 and ER, PR in epithelial and stromal endometrium by using immunohistochemical methods.
Results and discussion. Increasing expression of the protein Кі-67 by the progression of stage of the proliferative process was identified as a result of immunohistochemical research. The receptor apparatus of endometrium was characterized by a predominance PR over ER by the simple and complex hyperplasia and predominance ER over PR by the atypical form.
Conclusions. Estrogens, in case of their own receptor predominance over progesterone receptors, have uncontrolled proliferative influence which is accompanied by elevated levels of expression of the proliferation marker Кі-67.