Purpose: Improvement of treatment of radiation reactions of the oral mucous membrane (OMM) in patients with neoplasms in the area of the head and neck who receive radiation therapy.
Material and methods. Clinical studies were made in 42 patients, suffering from OMM affection after radiation therapy of neoplasms in the area of the head and neck. All patients were divided into 2 groups: control and basic. The control included 20 patients who received traditional medical measures with inclusion of the local classical method of applications with the olive oil. The patients of the basic group (22 persons) received gel “Apident” 3 times a day within 2 weeks, which the patients applied by themselves. A degree of severity of radiation reactions of the oral mucous membrane was estimated according to the scale RTOG (Radiation Therary Oncology Group) of Acute Radiation Morbidity Scoring Criteria, a degree of expressiveness of xerostomia was determined by summarizing objective examinations and subjective semiology taking into the account secretion rate of the salivary glands. There were observed a hygienic condition of the oral cavity, presence and intensity of inflammation using classical methods.
Results. The application of the gel “Apident” in the complex therapy of radiation reactions of OMM in patients with neoplasms in the area of the head and neck after radiation treatment influenced favorably the objective and subjective symptoms of radiation reactions.
In comparison with patients who were given local anti-inflammatory therapy by traditional methods, the patients with application of the apigel were observed to have fast healing of edema, OMM erosion, there were less often marked gingival hemorrhage, phenomena of focal and confluent epitheliitis, ulcerous-necrotic processes. There was observed reduction in the xerostomia level manifestation that promoted improvement of the hygienic condition of the oral cavity, prevention of the secondary microbic colonization of the damaged mucous surfaces. The application of the gel “Apident” reduced terms of restoration of the structural-functional integrity of OMM that improves quality of life of the patients and promoted their rehabilitation.
Conclusions. The local application of the gel “Apident” in the complex therapy of radiation reactions of OMM in patients with neoplasms in the area of the head and neck who underwent radiation treatment reduces radiation reactions manifestations more quickly and stops them.
Inclusion of the apigel in the scheme of treatment promotes reduction of the xerostomia level, improvement of the hygienic condition of the oral cavity.
Results of the studies are evidence of perspectivity of the application of the gel “Apident” in treatment and prevention of radiation reactions in OMM in patients with neoplasms in the area of the head and neck after radiation therapy for improvement of the quality of life and level of rehabilitation.