As a result of investigation of streptomycin and ethambutol effects on cytochrome P-450 2E1-dependent mechanisms of hepatotoxicity we have demonstrated great differences in their effects on cytochrome P-450 2E1 induction, NADPH-dependent lipid peroxidation, levels of II phase of biotransformation parameters and nuclear DNA fragmentation. Simultaneously effects of antitubercular combinations 1 and 2 on parameters of biotransformation phases I and II, pro- and antioxidant status and hepatocytes nuclear DNA fragmentation were the same.
