INFLUENCE OF CYNAZEPAM AND 3-HYDROXY-BD ON SLEEP-WAKE UP CYCLE IN INTACT AND REZERPINE RATS

Basing on the EEG data analysis results of cynazepam and 3-hydroxy-BD influence on the structure of sleep in rats, it was established that the use of cynazepam (2.5 mg/kg) causes a decrease in the duration of wake up phase, and increases the duration of slow wave sleep, while as the use of 3-hydroxy-BD (2.5 mg/kg) causes only the extension phase of the superficial slow wave sleep in intact rats. Cynazepam (2.5 mg/kg) normalizes the duration of the superficial slow wave sleep, increases the duration of the paradoxical sleep (PS) and reduces its fragmentation in the rats with a syndrome of disorders in the sleep — wake up cycle — caused by the use of reserpine.