The purpose of the study was to examine BNP Nt-pro level and parameters of systolic and diastolic functions of myocardium of patients with stable angina (SA) with saved systolic function (SSF) of the left ventricleLV during physical load tests.
Materials and methods. 52 patients (men at average age (52.4±1.5) years) with SA of II-III class were included into the study. All 52 patients had two dimensional echocardiography, Doppler and treadmill test, NT-proBNP concentration of blood plasma was defined.
Results. It was defined that at height of load tests in groups of patients with NT-proBNP level more than 125 pg/ml in comparison with group of patients with normal level of NT-proBNP, we can observe more definite decrease of systolic and diastolic functions ofLV and definite increase of BNP NT-pro level. Among all cases under analyses in 30.7% of cases systolic dysfunction (FV (47.5±4.0) %) with NT-proBNP level of (241,5±22) pg/ml and in 38.5% of cases diastolic dysfunction ofLV (E/A 0.76±0.01) with NT-proBNP level of (280±20) pg/ml were found out. For patients with SA and SSF of LV with normal NT-proBNP level is appropriate to define NT-proBNP level at rest condition, however markers of functional condition of heart should be defined during physical load for early diagnosis of dysfunctions of myocardium.