Today cardiovascular pathology remains the leading cause of morbidity and mortality of population ofUkraine.
The aim of the study was to determine the dynamics of neopterin in patients with stable angina and obesity depending on the degree of stenosis of coronary vessels on the basis of the coronarography.
Material and methods. We examined 110 patients with stable angina of II–III functional class. All the patients with stable angina were divided into 2 groups: the first group comprised patients with stable angina with concomitant obesity (n=80), the second group included patients with stable angina without obesity (n=30). Obesity was determined by IDF classification. Neopterin level was assessed by immunoenzyme methods using immunoenzyme analyzer “LabLine-90”. 39 patients with diagnosed stable angina and concomitant obesity were performed coronrography.
Conclusion. As the growth of stable angina functional class was noted a significant increase of neopterin, indicating the activation of cellular immune responses and can be regarded neopterin as a marker of development and progression of stable angina, due to the development of immune inflammation. Increasing stenosis due to atherosclerotic plaque installed according to coronary angiography, there was a significant increase of neopterin, indicating the degree of correlation of expression and prevalence of atherosclerotic vascular lesions and neopterin levels, which in turn allows us to consider increased neopterin as a marker of risk factor of coronary artery disease complications development, as evidenced by the obtained correlation.