Introduction. Numerous experimental and clinical studies have shown that the ratio of different biological corpuscles (macromolecules, immune complexes) of blood plasma in the nanometer range to some extent indicates the state of homeostasis of internal organism state. At various diseases depending on the etiological factors, pathogenetic mechanisms and severity of the disease, there are significant variations in the corpuscle ratio. These violations are detected by the laser correlation spectroscopy method.
Materials and methods. The state of the hemostasis system in patients with tuberculosis was evaluated with the help of the laser correlative spectroscopy analyzer of the blood plasma as well as by the use of a standard complex of laboratory coagulation tests.
Results and conclusions. Definition of a condition of the hemostasis system state of the patients with tuberculosis before and two months after the beginning of an intensive care course therapy using the standard coagulogram revealed shifts towards coagulation (p<0.05) and a tendency to fibrinolysis depressing. The revealed changes were statistically accompanied (p<0.05) by increase in a contribution to a light dispersion of corpuscles with a hydrodynamic radius from 12 to 38 nanometers and decrease in a contribution of corpuscles from 39 to 95 nanometers that points to a dominance of intoxicational-like processes in homeostasis system. Two months after the beginning of treatment it was noted a reliable (p<0.05) increase in a light dispersion contribution of large corpuscles from 39 to 264 nanometers that is inherent in autoimmune intoxicational-like shifts of LC-spectrum of blood plasma which is accompanied with reliable (p<0.05) increase of level of the tests characterizing coagulative processes in dynamics.